HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (cis)-3-Methyl-4-pyrrolidin-1-yl-piperidine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | (cis)-3-Methyl-4-(2-oxo-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 67314227 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (cis)-3-Methyl-4-pyrrolidin-1-yl-piperidine dihydrochloride | HCID 67315322 | — |
Reaction Steps
The title compound was prepared in analogy to 193B, by reduction of (cis)-3-methyl-4-(2-oxo-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Example 195B) with lithium aluminium hydride and subsequent deprotection with 4M hydrochloric acid in dioxane. MS: 169.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977358B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-4ec4833624c3424c86473045b56314e0 |
| Source note | uspto-grants-2011_07 |