HCID 67314549, compound → HCID 57554988, compound

HRID 1012015Notes

Reaction equation

HRID 1012015 reaction equation
[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([OH:22])=O)[CH2:3][CH2:2]1.Cl.Cl.[CH3:25][C@H:26]1[CH2:31][C@H:30]([N:32]2[CH2:36][CH2:35][CH2:34][CH2:33]2)[CH2:29][CH2:28][NH:27]1>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:17])([F:16])[F:18])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:27]2[CH2:28][CH2:29][C@@H:30]([N:32]3[CH2:36][CH2:35][CH2:34][CH2:33]3)[CH2:31][C@@H:26]2[CH3:25])=[O:22])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 67314549HCID 67314549, compoundHCID 673145935-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 57554988HCID 57554988, compound

Procedure

The title compound was prepared from 5-cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid (Example 181A) and (trans)-2-methyl-4-pyrrolidin-1-yl-piperidine dihydrochloride (example 199B) in direct analogy to the general procedure used in example 150. MS: 461.2 (MH+).

Sources & evidence

ORD record
ord-cac9875c976848d690c35abd155917ec
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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