HRID1012019

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66901605

未命名化合物

结构：Cc1nn(-c2cccc(C(F)(F)F)c2)c(C2CC2)c1C(=O)N1CCC(=O)CC1

HCID67314190

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N[C@@H]1C[C@@H](CO)N(C2CCN(C(=O)c3c(C)nn(-c4cccc(C(F)(F)F)c4)c3C3CC3)CC2)C1

HCID57555077

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 1-[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-one (Example 181B) and N-((3R,5S)-5-hydroxymethyl-pyrrolidin-3-yl)-acetamide hydrochloride in direct analogy to the general procedure used in example 129. MS: 534.2 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ae5e5869461b4176ae08fd609c73fd4d
来源数据集: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07977358B2
来源说明: uspto-grants-2011_07

反应 SMILES

[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:22]2[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]2)=[O:21])[CH2:3][CH2:2]1.Cl.[OH:30][CH2:31][C@H:32]1[NH:36][CH2:35][C@H:34]([NH:37][C:38](=[O:40])[CH3:39])[CH2:33]1>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:16])[F:17])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:22]2[CH2:27][CH2:26][CH:25]([N:36]3[C@H:32]([CH2:31][OH:30])[CH2:33][C@@H:34]([NH:37][C:38](=[O:40])[CH3:39])[CH2:35]3)[CH2:24][CH2:23]2)=[O:21])[CH2:3][CH2:2]1