[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-one → HCID 57554952, compound

HRID 1012020Notes

Reaction equation

HRID 1012020 reaction equation
[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:22]2[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]2)=[O:21])[CH2:3][CH2:2]1.Cl.[OH:30][CH2:31][C@@H:32]1[C@H:36]([NH:37][C:38](=[O:40])[CH3:39])[CH2:35][CH2:34][NH:33]1>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[N:7]=[C:6]([CH3:19])[C:5]=2[C:20]([N:22]2[CH2:27][CH2:26][CH:25]([N:33]3[CH2:34][CH2:35][C@@H:36]([NH:37][C:38](=[O:40])[CH3:39])[C@H:32]3[CH2:31][OH:30])[CH2:24][CH2:23]2)=[O:21])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 67314190[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-oneHCID 67314794HCID 67314794, compound

Product 1

HCID 57554952HCID 57554952, compound

Procedure

The title compound was prepared from 1-[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-one (Example 181B) and N-((2S,3R)-2-hydroxymethyl-pyrrolidin-3-yl)-acetamide hydrochloride in direct analogy to the general procedure used in example 129. MS: 534.2 (MH+).

Sources & evidence

ORD record
ord-53e441c6114842d6bb73eec9318bc7cc
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

Loading…