4-(1-Pyrrolidinyl)piperidine → [5-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

HRID 1012021Notes

Reaction equation

HRID 1012021 reaction equation
[CH:1]1([C:4]2[N:8]([C:9]3[CH:14]=[CH:13][C:12]([O:15][C:16]([F:19])([F:18])[F:17])=[CH:11][CH:10]=3)[N:7]=[C:6]([CH3:20])[C:5]=2[C:21](O)=[O:22])[CH2:3][CH2:2]1.[N:24]1([CH:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:1]1([C:4]2[N:8]([C:9]3[CH:10]=[CH:11][C:12]([O:15][C:16]([F:19])([F:18])[F:17])=[CH:13][CH:14]=3)[N:7]=[C:6]([CH3:20])[C:5]=2[C:21]([N:32]2[CH2:33][CH2:34][CH:29]([N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[CH2:30][CH2:31]2)=[O:22])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 673148045-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 57555046[5-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

Procedure

The title compound was prepared from 5-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid and 4-pyrrolidin-1-yl-piperidine in direct analogy to the general procedure used in example 150. MS: 463.2 (MH+).

Sources & evidence

ORD record
ord-7e24c52c506840ed9c9826edd16dfc09
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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