HCID 178522426, compound → HCID 178522424, compound

HRID 1012100Notes

Reaction equation

HRID 1012100 reaction equation
Cl[C:2]1[CH:31]=[CH:30][CH:29]=[C:28](Cl)[C:3]=1[C:4]([NH:6][C:7]1[C:8]([C:12]2[NH:16][C:15]3[CH:17]=[CH:18][C:19]([CH2:21][N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[CH:20][C:14]=3[N:13]=2)=[N:9][NH:10][CH:11]=1)=[O:5].[O:33]1C2C=CC=C(C(NC3C(C(O)=O)=NNC=3)=O)C=2[O:36][CH2:35][CH2:34]1>>[N:22]1([CH2:21][C:19]2[CH:18]=[CH:17][C:15]3[NH:16][C:12]([C:8]4[C:7]([NH:6][C:4]([C:3]5[C:28]6[O:36][CH2:35][CH2:34][O:33][C:29]=6[CH:30]=[CH:31][CH:2]=5)=[O:5])=[CH:11][NH:10][N:9]=4)=[N:13][C:14]=3[CH:20]=2)[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 178522426HCID 178522426, compoundHCID 1785224494-[(2,3-dihydro-benzo[1,4]dioxine-5-carbonyl)-amino]-1H-pyrazole-3-carboxylic acid

Product 1

HCID 178522424HCID 178522424, compound

Procedure

The compound was prepared in a manner analogous to 2,6-dichloro-N-[3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-benzamide (Example 94E), but using 4-[(2,3-dihydro-benzo[1,4]dioxine-5-carbonyl)-amino]-1H-pyrazole-3-carboxylic acid to give 2,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid [3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-amide (39 mg) as a pink solid. (LC/MS: Rt 1.99, [M+H]+ 461.23).

Sources & evidence

ORD record
ord-52c8bb9deda546b086abc303b540f5a6
Source dataset
uspto-grants-2011_07
Patent number
US07977477B2

Reaction notes

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