(3,4-diaMinophenyl)(Morpholino)Methanone → 2,6-dichloro-N-{3-[5-(morpholine-4-carbonyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}-benzamide

HRID 1012101Notes

Reaction equation

HRID 1012101 reaction equation
[Cl:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[C:3]=1[C:4]([NH:6][C:7]1[C:8]([C:12]2[NH:16][C:15]3[CH:17]=[CH:18][C:19]([CH2:21][N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[CH:20][C:14]=3[N:13]=2)=[N:9][NH:10][CH:11]=1)=[O:5].NC1C=C(C(N2CCOCC2)=[O:42])C=CC=1N>>[Cl:32][C:28]1[CH:29]=[CH:30][CH:31]=[C:2]([Cl:1])[C:3]=1[C:4]([NH:6][C:7]1[C:8]([C:12]2[NH:16][C:15]3[CH:17]=[CH:18][C:19]([C:21]([N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)=[O:42])=[CH:20][C:14]=3[N:13]=2)=[N:9][NH:10][CH:11]=1)=[O:5]

Participants

3

Reactant 2

HCID 22411123(3,4-diaMinophenyl)(Morpholino)MethanoneHCID 178522426HCID 178522426, compound

Product 1

HCID 1785224342,6-dichloro-N-{3-[5-(morpholine-4-carbonyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}-benzamide

Procedure

The compound was prepared in a manner analogous to 2,6-dichloro-N-[3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-benzamide (Example 94E), but using (3,4-diamino-phenyl)-morpholin-4-yl-methanone (Example 94B) to give 2,6-dichloro-N-{3-[5-(morpholine-4-carbonyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}-benzamide (17 mg) as a beige solid. (LC/MS: Rt 2.98, [M+H]+ 485.13).

Sources & evidence

ORD record
ord-0e4c0554ee154d4892e4ca2eff20f6a6
Source dataset
uspto-grants-2011_07
Patent number
US07977477B2

Reaction notes

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