HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3,4-diaMinophenyl)(Morpholino)Methanone → 2-chloro-6-fluoro-N-{3-[5-(morpholine-4-carbonyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3,4-diaMinophenyl)(Morpholino)Methanone | HCID 22411123 | — |
| Reactant | HCID 178522426 | HCID 178522426 | — |
| Reactant | 4-(2-Chloro-6-fluorobenzamido)-1H-pyrazole-5-carboxylic acid | HCID 178524953 | — |
| Product | 2-chloro-6-fluoro-N-{3-[5-(morpholine-4-carbonyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}-benzamide | HCID 178522435 | — |
Reaction Steps
The compound was prepared in a manner analogous to 2,6-dichloro-N-[3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-benzamide (Example 94E), but using 4-(2-chloro-6-fluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid (Example 95A) and (3,4-diamino-phenyl)-morpholin-4-yl-methanone (Example 94B) to give 2-chloro-6-fluoro-N-{3-[5-(morpholine-4-carbonyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}-benzamide (18 mg) as a beige solid. (LC/MS: Rt 2.89, [M+H]+ 469.15).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977477B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-e8e9adbfbbd34434b57cbc3d1db700c7 |
| Source note | uspto-grants-2011_07 |