1,2-Diamino-3,5-bis(trifluoromethyl)benzene → HCID 178522439, compound

HRID 1012105Notes

Reaction equation

HRID 1012105 reaction equation
ClC1C=CC=C(Cl)C=1C(NC1C(C2NC3C=CC(CN4CCOCC4)=CC=3N=2)=NNC=1)=O.[F:33][C:34]1[CH:50]=[CH:49][CH:48]=[C:47]([F:51])[C:35]=1[C:36]([NH:38][C:39]1[C:40]([C:44](O)=O)=[N:41][NH:42][CH:43]=1)=[O:37].[F:52][C:53]([F:67])([F:66])[C:54]1[C:55]([NH2:65])=[C:56]([NH2:64])[CH:57]=[C:58]([C:60]([F:63])([F:62])[F:61])[CH:59]=1>>[F:52][C:53]([F:66])([F:67])[C:54]1[C:55]2[N:65]=[C:44]([C:40]3[C:39]([NH:38][C:36](=[O:37])[C:35]4[C:34]([F:33])=[CH:50][CH:49]=[CH:48][C:47]=4[F:51])=[CH:43][NH:42][N:41]=3)[NH:64][C:56]=2[CH:57]=[C:58]([C:60]([F:61])([F:62])[F:63])[CH:59]=1

Participants

4

Reactant 3

HCID 27732141,2-Diamino-3,5-bis(trifluoromethyl)benzeneHCID 178522426HCID 178522426, compoundHCID 178524954HCID 178524954, compound

Product 1

HCID 178522439HCID 178522439, compound

Procedure

The compound was prepared in a manner analogous to 2,6-dichloro-N-[3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-benzamide (Example 94E), but using 4-(2,6-difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid (Example 16D) and 3,5-bis(trifluoromethyl)-1,2-diaminobenzene to give N-[3-(4,6-bis-trifluoromethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-2,6-difluoro-benzamide (51 mg) as a pink solid. (LC/MS: Rt 3.64, [M+H]+ 476.07).

Sources & evidence

ORD record
ord-50ee3e63e39748939f6c3abe7a67b12d
Source dataset
uspto-grants-2011_07
Patent number
US07977477B2

Reaction notes

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