4,5-Dichloro-1,2-phenylenediamine → HCID 178522422, compound

HRID 1012106Notes

Reaction equation

HRID 1012106 reaction equation
ClC1C=CC=C(Cl)C=1C(NC1C(C2NC3C=CC(CN4CCOCC4)=CC=3N=2)=NNC=1)=O.[F:33][C:34]1[CH:50]=[CH:49][CH:48]=[C:47]([F:51])[C:35]=1[C:36]([NH:38][C:39]1[C:40]([C:44](O)=O)=[N:41][NH:42][CH:43]=1)=[O:37].[Cl:52][C:53]1[C:58]([Cl:59])=[CH:57][C:56]([NH2:60])=[C:55]([NH2:61])[CH:54]=1>>[Cl:52][C:53]1[C:58]([Cl:59])=[CH:57][C:56]2[NH:60][C:44]([C:40]3[C:39]([NH:38][C:36](=[O:37])[C:35]4[C:34]([F:33])=[CH:50][CH:49]=[CH:48][C:47]=4[F:51])=[CH:43][NH:42][N:41]=3)=[N:61][C:55]=2[CH:54]=1

Participants

4

Reactant 3

HCID 792974,5-Dichloro-1,2-phenylenediamineHCID 178522426HCID 178522426, compoundHCID 178524954HCID 178524954, compound

Product 1

HCID 178522422HCID 178522422, compound

Procedure

The compound was prepared in a manner analogous to 2,6-dichloro-N-[3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-benzamide (Example 94E), however using 4-(2,6-difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid (Example 16D) and 4,5-dichloro-1,2-phenylene diamine to give N-[3-(5,6-dichloro-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-2,6-difluoro-benzamide (29 mg) as a beige solid. (LC/MS: Rt 3.53, [M+H]+ 408.02).

Sources & evidence

ORD record
ord-9798d548f6714f87b858177c75d9e25e
Source dataset
uspto-grants-2011_07
Patent number
US07977477B2

Reaction notes

Loading…