HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1012110Generated: October 27, 2026
2-Fluoropyridine → N-[3-(2H-Benzimidazol-2-ylidene)-2,3-dihydro-1H-pyrazol-4-yl]pyridin-2-amine
https://huagongshe.com/reaction/1012110
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Fluoropyridine | HCID 9746 | — |
| Reactant | HCID 178508052 | HCID 178508052 | — |
| Product | N-[3-(2H-Benzimidazol-2-ylidene)-2,3-dihydro-1H-pyrazol-4-yl]pyridin-2-amine | HCID 178420478 | 5.8% |
Reaction Steps
A mixture of 3-(1H-benzimidazol-2-yl)-1H-pyrazol-4-ylamine (150 mg, 0.75 mmol) and 2-fluoropyridine (0.26 ml, 3.0 mmol) was heated in the microwave at 150° C. and 100 W for 15 min. Petroleum ether was added and the solid formed collected by filtration. Recrystallisation from methanol gave [3-(1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-pyridin-2-yl-amine (12 mg). (LC/MS: Rt 0.91, [M+H]+ 277.00).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07977477B2 |
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| Source dataset | uspto-grants-2011_07 |
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| ORD ID | ord-9ec182b558744181939bff438b0efd82 |
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| Source note | uspto-grants-2011_07 |
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