反应详情

A mixture of 4-(4-methyl-benzoylamino)-1H-pyrazole-3-carboxylic acid methyl ester (486 mg) in 2 M aqueous NaOH/MeOH (1:1, 50 ml) was stirred at ambient temperature for 14 h. Volatile materials were removed in vacuo, water (100 ml) added and the mixture taken to pH 5 using 2M aqueous HCl. The resultant precipitate was collected by filtration and dried through azeotrope with toluene to afford 4-(4-methyl-benzoylamino)-1H-pyrazole-3-carboxylic acid as a gray solid (345 mg). (LC/MS: Rt 2.35, [M+H]+ 246.09).

1. customVolatile materials were removed in vacuo, water (100 ml)
2. additionadded
3. filtrationThe resultant precipitate was collected by filtration
4. dry with materialdried through azeotrope with toluene