4,5-Dimethyl-1,2-phenylenediamine → HCID 178425844, compound

HRID 1012113Notes

Reaction equation

HRID 1012113 reaction equation
ClC1C=CC=C(Cl)C=1C(NC1C(C2NC3C=CC(CN4CCOCC4)=CC=3N=2)=NNC=1)=O.[CH3:33][C:34]1[CH:50]=[CH:49][C:37]([C:38]([NH:40][C:41]2[C:42]([C:46](O)=O)=[N:43][NH:44][CH:45]=2)=[O:39])=[CH:36][CH:35]=1.[CH3:51][C:52]1[CH:53]=[C:54]([NH2:60])[C:55]([NH2:59])=[CH:56][C:57]=1[CH3:58]>>[CH3:51][C:52]1[C:57]([CH3:58])=[CH:56][C:55]2[NH:59][C:46]([C:42]3[C:41]([NH:40][C:38](=[O:39])[C:37]4[CH:49]=[CH:50][C:34]([CH3:33])=[CH:35][CH:36]=4)=[CH:45][NH:44][N:43]=3)=[N:60][C:54]=2[CH:53]=1

Participants

4

Reactant 3

HCID 766354,5-Dimethyl-1,2-phenylenediamineHCID 1784258454-(4-Methylbenzamido)-1H-pyrazole-5-carboxylic acidHCID 178522426HCID 178522426, compound

Product 1

HCID 178425844HCID 178425844, compound

Procedure

The compound was prepared in a manner analogous to 2,6-dichloro-N-[3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-benzamide, however using 4-(4-methyl-benzoylamino)-1H-pyrazole-3-carboxylic acid and 4,5-dimethylbenzene-1,2-diamine to give N-[3-(5,6-dimethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-4-methyl-benzamide (32 mg) as a white solid. (LC/MS: Rt 3.42, [M+H]+ 346.26).

Sources & evidence

ORD record
ord-af8d9aca6e24440f9f4d21f0f5c2c13f
Source dataset
uspto-grants-2011_07
Patent number
US07977477B2

Reaction notes

Loading…