Tetrahydrofuran → HCID 178514081, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-ylamine (70 mg, 0.23 mmol), morpholine-4-carbonyl chloride (80 μl, 0.7 mmol) and diisopropylethylamine (170 μl, 0.92 mmol) in THF (2 ml) was stirred at 0° C. and then allowed to warm to room temperature over 16 h. The reaction was quenched by the addition of conc. aq. NH3 and then concentrated in vacuo. The residue was purified through preparative LC/MS to give 4-morpholinyl-N-[3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1-H-pyrazol-4-yl]-urea as a white solid (35 mg). (LC/MS (basic method): Rt 2.28 min, [M−H+]− 415).

Provenance & Evidence