Toluene → HCID 178510929, compound

Participants

Reaction Steps

A solution of 5-(tert-butoxycarbonylamino-propyl)-2-[4-(2,6-difluoro benzoylamino)-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-1H-imidazole-4-carboxylic acid (300 mg, 0.52 mmoles) and anisole (114 μl, 1.04 mmoles) in TFA (3 ml) was heated at 100° C. (80 W) in a CEM discover microwave synthesizer for 10 minutes. Toluene (10 ml) was added and the solvent removed in vacuo to give 5-(3-amino-propyl)-2-[4-(2,6-difluoro-benzoylamino)-1H-pyrazol-3-yl]-1H-imidazole carboxylic acid as a yellow/brown solid (200 mg, 99%). (LC/MS: Rt 1.58, {M+H]+ 391.00).

Provenance & Evidence