HCID 178499180, compound → HCID 178499176, compound

Participants

Reaction Steps

A mixture of 4-nitro-1H-pyrazole-3-carboxylic acid methyl ester (10 g, 58 mmol) and 10% palladium on carbon (500 mg) in ethanol (150 ml) and DMF (30 ml) stirred under an atmosphere of hydrogen overnight. The reaction mixture was filtered through celite reduced in vacuo and dried through azeotrope with toluene and methanol to afford 4-amino-1H-pyrazole-3-carboxylic acid methyl ester as a dark amber tar (9.35 g). (LC/MS (acidic): Rt 0.39 min, [M+H]+ 142).

Provenance & Evidence