1,2-Dichloroethane → HCID 178490078, compound

Participants

Reaction Steps

To a solution of EDC (720 mg, 3.8 mmol), HOBt (510 mg, 3.8 mmol) and 4-(5-tert-butyl-2-methoxy-benzoylamino)-1H-pyrazole-3-carboxylic acid (1 g, 3.16 mmol) in DMF (25 ml) was added benzene-1,2-diamine (375 mg, 3.5 mmol) and the mixture stirred at room temperature for 5 hours. The mixture was reduced in vacuo and the residue partitioned between EtOAc (50 ml) and brine (2×50 ml). Undissolved precipitate was removed by filtration, the organic portions washed with saturated aqueous sodium hydrogen carbonate (50 ml), dried (MgSO4) and reduced in vacuo to yield 4-(5-tert-butyl-2-methoxy-benzoylamino)-1H-pyrazole-3-carboxylic acid (2-amino-phenyl)-amide as a pale yellow powder (848 mg, 66%). (LC/MS (acidic method): Rt 3.21 min, [M+H]+ 408).

Provenance & Evidence