反应详情

To a solution of N-[4-methoxy-5-(4-methyl-piperidin-1-ylmethoxy)-2-nitro-phenyl]-acetamide (1.34 g, 3.97 mmol) in MeOH (40 ml) was added sodium methoxide (1 g, 18.5 mmol) reaction stirred RT for 48 hours then reduced in vacuo. The residue was triturated with water and the solid filtered and washed with further water. Solid dried to yield 4-Methoxy-5-(4-methyl-piperidin-1-ylmethoxy)-2-nitro-phenylamine (0.9 g), (LC/MS (acidic method): Rt 1.72, [M+H]+ 296)

1. customThe residue was triturated with water
2. filtrationthe solid filtered
3. washwashed with further water
4. customSolid dried