5-Chloro-o-anisic acid → HCID 178490649, compound

HRID 1012167Notes

Reaction equation

HRID 1012167 reaction equation
FC1C=CC=C(F)C=1C([NH:6][C:7]1[C:8]([C:12]([OH:14])=[O:13])=[N:9][NH:10][CH:11]=1)=O.[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([O:30][CH3:31])=[C:25]([CH:29]=1)[C:26]([OH:28])=O>>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([O:30][CH3:31])=[C:25]([CH:29]=1)[C:26]([NH:6][C:7]1[C:8]([C:12]([OH:14])=[O:13])=[N:9][NH:10][CH:11]=1)=[O:28]

Participants

3

Reactant 2

HCID 769705-Chloro-o-anisic acidHCID 178524954HCID 178524954, compound

Product 1

HCID 178490649HCID 178490649, compound

Procedure

The compound was prepared in a manner analogous to 4-(2,6-difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid (Example 16D), but using 5-chloro-2-methoxy-benzoic acid as the starting acid to give 4-(5-chloro-2-methoxy-benzoylamino)-1H-pyrazole-3-carboxylic acid (12 g) as a colourless solid. (LC/MS: Rt 2.48, [M−H+]− 294)

Sources & evidence

ORD record
ord-0f6f60f0497f46599fa4fa5985b3607e
Source dataset
uspto-grants-2011_07
Patent number
US07977477B2

Reaction notes

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