Acetovanillone → HCID 86633101, compound

Participants

Reaction Conditions

Reaction Steps

To a N2 purged flask was added 2,4-bis-trifluoromethyl benzyl bromide (2.21 g, 7.20 mmol), acetovanillone (1.32 g, 7.92 mmol), and DMF (15 mL). To the reaction solution was added fine mesh K2CO3 (3 equiv, 21.6 mmol). The reaction was allowed to stir at 70° C. for 1 h, then at 60° C. for 14 h. The reaction solution was then diluted with EtOAc (150 mL), filtered through a Buchner funnel, washed with sat'd NH4Cl (70 mL×2) washed with sat NaCl (50 mL), dried over Na2SO4, and then filtered and concentrated in vacuo to provide a crude product (2.8 g, 99% yield).

Provenance & Evidence