HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → 5-Chloro-1,3-dimethyl-1h-pyrazole-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | 5-Chloro-1,3-dimethylpyrazole-4-carboxaldehyde | HCID 2777397 | — |
| Solvent | 1,2-Dichlorobenzene | HCID 7239 | — |
| Product | 5-Chloro-1,3-dimethyl-1h-pyrazole-4-carbonyl chloride | HCID 11745492 | 72% |
Reaction Steps
Simultaneously, 68 g of sulphuryl chloride and 70.5 g of a 2.5% solution of 2,2-azoisobutyronitrile (AIBN) are added dropwise at 80° C. to 300 g of a 22.7% solution of 5-chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde in 1,2-dichlorobenzene within 4 hours. After the metered addition has ended, the reaction solution is stirred for a further 2 hours. After removal of the solvent, 5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl chloride is obtained in a yield of 72%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977494B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-80fa4179ae2c4ba594ab6d9900819551 |
| Source note | uspto-grants-2011_07 |