Hydrochloric Acid → Venom

Participants

Reaction Steps

18.75 g of sodium chloride, 115.0 g of water, 3.01 g (0.07 mole) of 96% NaOH and [(3-tetrahydrofuryl)methyl]amine (39.9 g, 0.39 mole) were mixed, and the resulting mixture was cooled to −10 degree centigrade. N,O-dimethyl-N′-nitroisourea (49.2 g, 0.37 mole) was introduced into the above solution. Sodium chloride was dissolved in water with 53% of the saturated solubility at a water temperature of −10 degree centigrade. The solution was stirred at −10 degree centigrade for 4 hours, heated to 0 degree centigrade, and further stirred for 19 hours. Then, 35% hydrochloric acid (13.1 g, 0.13 mole) was added to the suspension so that the pH became not more than 4. The suspension was heated and dissolved for carrying out recrystallization. The precipitated crystal was filtered, and the filtered crystal was washed with cold water and then dried. 59 g of a 1-methyl-2-nitro-3-[(3-tetrahydrofuryl)methyl]guanidine with a purity of 99% was obtained. The isolated yield at this time was 78%.

Provenance & Evidence