Acetone → HCID 86663349, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (S)-[2-(4-benzyloxyphenyl)-1-thiocarbamoylethyl]carbamate (250 mg, 0.647 mmol) in acetone (5 ml) was added bromoacetaldehyde diethyl acetal (149 μl, 0.970 mmol), and the mixture was stirred at 65° C. for 14 hr. The mixture was further heated to 75° C. and stirred for 5 hr. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel chromatography (hexane:ethyl acetate=4:1) to give text-butyl (S)-[2-(4-benzyloxyphenyl)-1-(thiazol-2-yl)ethyl]carbamate (112 mg, yield 42%).

Provenance & Evidence