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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1012362Generated: October 26, 2026

N-(6-((2,5-Dioxopyrrolidin-1-yl)oxy)-6-oxohexyl)-6-((5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno(3,4-d)imidazol-4-yl)pentanoyl)amino)hexanamide → Biotinyl-lysine

https://huagongshe.com/reaction/1012362

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(6-((2,5-Dioxopyrrolidin-1-yl)oxy)-6-oxohexyl)-6-((5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno(3,4-d)imidazol-4-yl)pentanoyl)amino)hexanamideHCID 16219024—
ReactantMaleimide-biotinHCID 22896102—
ProductBiotinyl-lysineHCID 18644438—

Reaction Steps

and 6-(biotinamidocaproylamido) caproic acid N-hydroxysuccinimide ester (Sigma-Aldrich, product B3295), biotinamidocaproate-N-hydroxysuccinimide ester (Sigma-Aldrich, product B2643), biotinamidocaproic acid 3-sulfo-N-hydroxysuccinimide ester (Sigma-Aldrich, product B1022) and biotin-maleimide (Sigma-Aldrich, product B1267).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07977500B2
Source datasetuspto-grants-2011_07
ORD IDord-1756a72e762b453c9241dd0accd58490
Source noteuspto-grants-2011_07