HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium hydride → 1-[(1,2-Dimethyl-1H-imidazol-4-yl)sulfonyl]-4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | 15-Crown-5 | HCID 36336 | — |
| Edukt | 1,2-Dimethylimidazole-4-sulfonyl chloride | HCID 2736256 | — |
| Edukt | 4-Methyl-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 71362812 | — |
| Produkt | 1-[(1,2-Dimethyl-1H-imidazol-4-yl)sulfonyl]-4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 86620765 | — |
Reaktionsschritte
By a reaction under similar conditions as in Reference Example 65 and using 4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde (185 mg), sodium hydride (60% in oil, 60 mg), 15-crown-5 (0.30 mL) and (1,2-dimethyl-1H-imidazol-4-yl)sulfonyl chloride (253 mg), the title compound was obtained as a colorless solid (yield 294 mg, 86%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07977488B2 |
| Quelldatensatz | uspto-grants-2011_07 |
| ORD ID | ord-caac8113109741f29d874e8626109775 |
| Quellennotiz | uspto-grants-2011_07 |