1-methyl-1H-pyrazole-4-sulfonyl chloride → HCID 86630981, compound

HRID 1012479Notes

Reaction equation

HRID 1012479 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:12][CH:11]=[C:10]([CH:13]=[O:14])[CH:9]=1.[CH3:15][N:16]1[CH:20]=[C:19]([S:21](Cl)(=[O:23])=[O:22])[CH:18]=[N:17]1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]([S:21]([C:19]2[CH:18]=[N:17][N:16]([CH3:15])[CH:20]=2)(=[O:23])=[O:22])[CH:11]=[C:10]([CH:13]=[O:14])[CH:9]=1

Participants

3

Reactant 2

HCID 170247301-methyl-1H-pyrazole-4-sulfonyl chlorideHCID 469085935-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde

Product 1

HCID 86630981HCID 86630981, compound

Procedure

By a similar operation as in Reference Example 65 and using 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde (189 mg) and 1-methyl-1H-pyrazole-4-sulfonyl chloride (217 mg), the title compound was obtained as yellow crystals (yield 217 mg, 65%).

Sources & evidence

ORD record
ord-75e0f8605db943949b7290283e18d3d9
Source dataset
uspto-grants-2011_07
Patent number
US07977488B2

Reaction notes

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