反应详情

After dissolving 9.07 g of the resulting hydrochloride (2aa) in 50 ml of water (pH=6.0), the mixture was neutralized with a 25% sodium hydroxide aqueous solution (pH=9.0 to 10.0), followed by extraction with 100 ml of chloroform twice. The chloroform layer was washed with 50 ml of a saturated sodium chloride aqueous solution, dried over anhydrous sodium sulfate, and concentrated, thereby obtaining 6.9 g of 4-[(4-dipropylaminobutyl)amino]methylbenzonitrile (2a) as a colorless oily substance (yield: 97%, GC: 99.4%).

1. extractionfollowed by extraction with 100 ml of chloroform twice
2. washThe chloroform layer was washed with 50 ml of a saturated sodium chloride aqueous solution
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated