Sodium Hydroxide → HCID 59850548, compound

Participants

Reaction Steps

7.81 g of the obtained 4-[(4-dipropylaminobutyl)amino]methylbenzylamine hydrochloride (5aa) was dissolved in 50 ml of water. After the addition of a 1N sodium hydroxide aqueous solution (pH=11), the mixture was extracted with 200 ml of chloroform, followed by 100 ml of chloroform. The chloroform layer was washed with 50 ml of water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure, thereby obtaining 5.62 g of 4-[(4-dipropylaminobutyl)amino]methylbenzylamine (5a) as a colorless oily substance (yield: 99%, GC: 99%).

Provenance & Evidence