Hydrochloric Acid → HCID 67314829, compound

Participants

Reaction Conditions

Reaction Steps

118.4 g (259 mmol, 1.0 equivalent) of {[4-(benzylidene)aminomethylbenzyl]-(4-dipropylaminobutyl)amino}ethyl acetate (8a) and 900 ml of ethanol were charged in a 3-liter four-necked flask and cooled to 0° C. The mixture was added dropwise with 870 ml (2.59 mol, 10 equivalents) of 3N hydrochloric acid over 2.5 hours and stirred at 0° C. for one hour and at 25° C. for 18 hours. About 5% of the raw material (8a) remained as a result of confirmation by HPLC. Therefore, the reaction solution was added with 110 ml of 2N hydrochloric acid at 25° C. After three hours, the content of the raw material (8a) was measured by HPLC, and it was confirmed that the content decreased to 1% or less.

Provenance & Evidence