Cesium carbonate → HCID 67315182, compound

Participants

Reaction Conditions

Reaction Steps

1-Bromo-2,4-difluorobenzene (87 μL, 0.77 mmol) was dissolved in 2.5 mL dry toluene under an argon atmosphere. Compound 462 (250 mg, 0.77 mmol) was added and dissolved in the solvent. 4,5-bis-diphenylphosphanyl-9,9-dimethyl-9H-xanthene (13 mg, 0.023 mmol), Pd(OAc)2 (3.5 mg, 0.015 mmol) and Cs2CO3 (352 mg, 1.08 mmol) were added, and the reaction mixture was stirred under an argon atmosphere at 120° C. for 24 h. The reaction mixture was filtered and then purified by flash chromatography using EtOAc/petroleum ether 1:2 as the eluent to afford the title compound as a solid.

Provenance & Evidence