Ethanesulfonyl chloride → HCID 58677678, compound

Participants

Reaction Steps

Compound 494 (0.045 g, 0.12 mmol) was dissolved in pyridine (0.3 mL). Ethanesulphonyl chloride (0.017 mL, 0.18 mmol) was added and the solution was stirred at room temperature for 1 h. The reaction mixture was concentrated in vacuo and the oil was dissolved in EtOAc and washed with H2O. The water phase was extracted with EtOAc and the combined organic phases were dried (MgSO4), filtered and concentrated in vacuo. The crude product was purified by flash chromatography using a gradient of EtOAc/petroleum ether (40-60) 15:85→40:60 as the eluent. This afforded the title compound as yellow solid. 13C NMR (CDCl3) δ 195.5, 159.3 (dd), 155.7 (dd), 148.3, 140.4, 135.3, 134.5, 134.5, 133.8, 132.5, 128.5, 124.6 (dd), 124.2 (dd), 123.2, 121.6, 116.1, 112.8, 111.6 (dd), 105.0 (dd), 45.9, 19.7, 8.1

Provenance & Evidence