Sodium Iodide → HCID 58677658, compound

Participants

Reaction Conditions

Reaction Steps

Compound 505 (0.05 g, 0.13 mmol) and 3-chloro-propanol (0.022 mL, 0.26 mmol) were dissolved in CH3CN (3 mL). K2CO3 (0.1 g, 0.72 mmol) and NaI (0.005 g, 0.03 mmol) were added and the suspension was heated in a microwave oven at 100° C. for 20 minutes. The suspension was filtered and the filtrate was concentrated in vacuo. The crude product was purified by flash chromatography using EtOAc/CH2Cl2 1:9 as the eluent. This afforded the title compound. 1H NMR (CDCl3) δ 7.36 (d, 1H), 7.22 (dd, 1H), 7.17 (d, 1H), 7.10 (d, 1H), 7.06-6.89 (m, 3H), 6.83 (dd, 1H), 6.79 (d, 1H), 5.88 (bs, 1H), 4.04 (t, 2H), 3.82 (t, 2H), 2.47 (s, 3H), 2.25 (s, 3H), 1.99 (m, 2H)

Provenance & Evidence