HCID 58677658, compound → HCID 58677571, compound

Participants

Reaction Steps

Compound 299 (0.026 g, 0.059 mmol) was dissolved in MeOH (2 mL). A catalytic amount of palladium on charcoal was added and the mixture was stirred under a hydrogen atmosphere for 1 h. The suspension was filtered and the filtrate was concentrated in vacuo. The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:1→3:1 as the eluent. This afforded the title compound. 1H NMR (CDCl3) δ 7.18 (dd, 1H), 7.11 (d, 1H), 7.03 (d, 1H), 7.00-6.80 (m, 3H), 6.76 (d, 1H), 6.45 (bs, 2H), 5.89 (dd, 1H), 5.75 (d, 1H), 5.59 (s, 1H), 4.08 (t, 2H), 3.83 (t, 2H), 2.22 (s, 3H), 2.18 (s, 3H), 2.01 (m, 2H)

Provenance & Evidence