HCID 11785333, compound → HCID 58677642, compound

HRID 1012663Notes

Reaction equation

HRID 1012663 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N+:15]([O-:17])=[O:16])[CH:5]=[CH:4][C:3]=1[C:18]([C:20]1[CH:25]=[C:24]([O:26][CH2:27][CH:28]2[CH2:32][O:31]C(C)(C)[O:29]2)[CH:23]=[CH:22][C:21]=1[F:35])=[O:19]>C(O)(C(F)(F)F)=O.O>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N+:15]([O-:17])=[O:16])[CH:5]=[CH:4][C:3]=1[C:18]([C:20]1[CH:25]=[C:24]([O:26][CH2:27][CH:28]([OH:29])[CH2:32][OH:31])[CH:23]=[CH:22][C:21]=1[F:35])=[O:19]

Participants

3

Reactant 1

HCID 11785333HCID 11785333, compound

Product 1

HCID 58677642HCID 58677642, compound

Reagents, catalysts & solvents 1

HCID 22392675Trifluoroacetic acid waterSolvent

Procedure

Compound 519 (46 mg, 0.092 mmol) was dissolved in TFA:H2O (3:1, 10 mL) and stirred at RT for 1 h. The reaction mixture was concentrated in vacuo and purified by flash chromatography using DCM/MeOH (v:v=4:1 to 1:4) as the eluent, affording the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. custompurified by flash chromatography

Sources & evidence

ORD record
ord-8d98ded5a51a4fdc9ab9979f058e31b0
Source dataset
uspto-grants-2011_07
Patent number
US07977387B2

Reaction notes

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