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HRID 1012670作成日：2026年10月25日

1,1-Dimethylhydrazine → 3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-benzoic acid N',N'-dimethyl-hydrazide

https://huagongshe.com/reaction/1012670

反応式

関与物質

役割名称HCID仕込み量
反応物1,1-DimethylhydrazineHCID 5976—
反応物3-[2-Chloro-4-(2,4-difluorophenylamino)benzoyl]-4-methylbenzoic acidHCID 58677602—
生成物3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-benzoic acid N',N'-dimethyl-hydrazideHCID 11259322—

反応手順

Compound 424 (50 mg, 0.12 mmol) and N,N-dimethyl-hydrazine (19 μL, 0.25 mmol) were treated as described for compound 337. Flash chromatography (ethyl acetate/petroleum ether: graduated from 67/33 to 80/20) provided the title compound. 13C NMR (DMSO-d6) δ 194.7, 163.2, 158.9 (dd), 155.9 (dd), 149.6, 139.6, 139.5, 133.9, 133.8, 131.3, 131.0, 129.1, 127.2, 126.7 (dd), 126.3, 124.2 (dd), 114.9, 112.0 (dd), 111.9, 105.1 (dd), 46.1, 19.6

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07977387B2
出典データセットuspto-grants-2011_07
ORD IDord-5118198a5b184289b10c2ccca0a7617b
出典メモuspto-grants-2011_07