Triphenylphosphine → HCID 67314508, compound

Participants

Reaction Conditions

Reaction Steps

In a screw-capped vial (8 mL) was placed dry degassed triethylamine (3.0 mL) and a magnetic stirrer under argon. Compound 543 (200 mg, 0.48 mmol), Pd2(dba)3 (9.0 mg, 0.01 mmol), triphenyl phosphine (13 mg, 0.048 mmol), CuI (2 mg) and ethynyl-trimethyl-silane (66 μL, 0.48 mmol) were added to the vial and the reaction mixture was heated under vigorously stirring at 90° C. for 20 h. The cooled reaction mixture was filtered through Decalite and concentrated in vacuo. The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) (v:v=5:95 to 30:70) as the eluent to afford the title compound as yellow foam.

Provenance & Evidence