HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxypropylamine → N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-(3-{[(3-methoxypropyl)amino]carbonyl}-phenyl)-1-benzofuran-2-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxypropylamine | HCID 1672 | — |
| Reactant | 3-(2-{[(3R)-1-Azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzofuran-7-yl)-benzoic acid hydrochloride | HCID 67313952 | — |
| Product | N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-(3-{[(3-methoxypropyl)amino]carbonyl}-phenyl)-1-benzofuran-2-carboxamide hydrochloride | HCID 67313944 | — |
Reaction Steps
50 mg (0.12 mmol) of 3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzofuran-7-yl)benzoic acid hydrochloride (Example 149) and 20.9 mg (0.23 mmol) of 3-methoxypropylamine are reacted together by general method E. 22.7 mg (36.4% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977485B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-eb3a3dd0c91e4dd1840cd5b4b2311d58 |
| Source note | uspto-grants-2011_07 |