2-Chloroethyl Isothiocyanate → HCID 16112879, compound

HRID 1012882Notes

Reaction equation

HRID 1012882 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[NH2:11].Cl[CH2:13][CH2:14][N:15]=[C:16]=[S:17]>C(OCC)C>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[NH:11][C:16]1[S:17][CH2:13][CH2:14][N:15]=1

Participants

4

Reactant 2

HCID 1386612-Chloroethyl IsothiocyanateHCID 162443174-Chloro-2,3-dihydro-1H-inden-1-amine

Product 1

HCID 16112879HCID 16112879, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of 4-chloro-indan-1-ylamine (390 mg) in diethyl ether (20 ml) was added 1-chloro-2-isothiocyanatoethane (283 mg) at 0° C. and the solution stirred for 2 h at the same temperature. The reaction mixture was quenched with diluted sodium hydroxide solution and extracted with diethyl ether. The residue was purified on silica gel to yield 240 mg of the product (41%).

Workup

  1. customThe reaction mixture was quenched with diluted sodium hydroxide solution
  2. extractionextracted with diethyl ether
  3. customThe residue was purified on silica gel

Sources & evidence

ORD record
ord-33624cd291bc44f1a3b17cc49442d76e
Source dataset
uspto-grants-2011_07
Patent number
US07981437B2

Reaction notes

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