HCID 74018134, compound → HCID 23118845, compound

HRID 1012897Notes

Reaction equation

HRID 1012897 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][CH3:11])[CH:5]=[C:4]([CH3:12])[C:3]=1[CH:13]=[CH:14][CH:15]1[CH2:20][CH2:19][CH:18]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:17][CH2:16]1.[H][H]>C1(C)C=CC=CC=1.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][CH3:11])[CH:5]=[C:4]([CH3:12])[C:3]=1[CH2:13][CH2:14][CH:15]1[CH2:20][CH2:19][CH:18]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:17][CH2:16]1

Participants

5

Reactant 2

HCID 74018134HCID 74018134, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23118845HCID 23118845, compoundYield 27.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 1140TolueneSolvent

Procedure

0.27 g of Pd/C was added to 6.53 g of the compound 1-1-3-18 having been dissolved in 50 mL of toluene and 50 mL of Solmix, and under a hydrogen atmosphere, the mixture was stirred at room temperature until hydrogen was not absorbed. Pd/C was removed, and the solvent was distilled off. The residue was purified by silica gel column chromatography and recrystallization to obtain 1.8 g of 1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-pentylcyclohexyl)ethane (Compound 1-1-3-5) as colorless crystals.

Workup

  1. customwas not absorbed
  2. customPd/C was removed
  3. distillationthe solvent was distilled off
  4. customThe residue was purified by silica gel column chromatography and recrystallization

Sources & evidence

ORD record
ord-30e142b763184adcb60c46848685fcab
Source dataset
uspto-grants-2011_07
Patent number
US07981486B2

Reaction notes

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