3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carbaldehyde → HCID 178516859, compound

HRID 1012913Notes

Reaction equation

HRID 1012913 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][CH:5]([C:8]([C:10]2[S:11][C:12]3[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=3[N:14]=2)=[O:9])[CH2:4][CH2:3]1.[O:19]=[C:20]1[NH:25][C:24]2[CH:26]=[C:27]([CH:30]=O)[CH:28]=[CH:29][C:23]=2[O:22][CH2:21]1>>[S:11]1[C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=[C:10]1[C:8]([C@H:5]1[CH2:6][CH2:7][C@H:2]([NH:1][CH2:30][C:27]2[CH:28]=[CH:29][C:23]3[O:22][CH2:21][C:20](=[O:19])[NH:25][C:24]=3[CH:26]=2)[CH2:3][CH2:4]1)=[O:9]

Participants

3

Reactant 2

HCID 107736383-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carbaldehydeHCID 67315824(4-Amino-cyclohexyl)-benzothiazol-2-yl-methanone

Product 1

HCID 178516859HCID 178516859, compoundYield 31.6%

Procedure

The title compound was prepared according to the same protocol as for example 1, step 1.c, using however (4-amino-cyclohexyl)-benzothiazol-2-yl-methanone (0.3 mmol) and 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde (0.3 mmol). 40 mg (28%) of the title compound (a yellowish solid) were obtained.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-2a0566a11c9f416684e2ea85dc7d01f7
Source dataset
uspto-grants-2011_07
Patent number
US07981886B2

Reaction notes

Loading…