2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde → HCID 178519928, compound

HRID 1012914Notes

Reaction equation

HRID 1012914 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([C:10]2[S:11][C:12]3[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=3[N:14]=2)=[O:9])[CH2:4][CH2:3]1.[O:19]1[C:24]2[CH:25]=[CH:26][C:27]([CH:29]=O)=[CH:28][C:23]=2[O:22][CH2:21][CH2:20]1>>[S:11]1[C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=[C:10]1[C:8]([C@H:5]1[CH2:6][CH2:7][C@H:2]([NH:1][CH2:29][C:27]2[CH:26]=[CH:25][C:24]3[O:19][CH2:20][CH2:21][O:22][C:23]=3[CH:28]=2)[CH2:3][CH2:4]1)=[O:9]

Participants

3

Reactant 2

HCID 2481272,3-Dihydro-1,4-benzodioxin-6-carbaldehydeHCID 178511558HCID 178511558, compound

Product 1

HCID 178519928HCID 178519928, compound

Procedure

The title compound was prepared according to the same protocol as for example 1, step 1.c, using however (trans-4-amino-cyclohexyl)-benzothiazol-2-yl-methanone (0.3 mmol) and 2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde (0.3 mmol). 93 mg (68%) of a beige solid were obtained.

Sources & evidence

ORD record
ord-1ff5541c1fe74d99bcd06626ed1b387f
Source dataset
uspto-grants-2011_07
Patent number
US07981886B2

Reaction notes

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