4-Methylbenzothiazole → HCID 178424117, compound

HRID 1012916Notes

Reaction equation

HRID 1012916 reaction equation
[CH3:1][C:2]1[C:7]2[N:8]=[CH:9][S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.C(O[C:16](=O)[NH:17][C@H:18]1[CH2:23][CH2:22][C@H:21]([C:24](=[O:29])N(OC)C)[CH2:20][CH2:19]1)(C)(C)C.[O:31]1[C:36]2[CH:37]=[CH:38][C:39](C=O)=[CH:40][C:35]=2[O:34][CH2:33][CH2:32]1>>[O:31]1[C:36]2[CH:37]=[CH:38][C:39]([CH2:16][NH:17][C@H:18]3[CH2:19][CH2:20][C@H:21]([C:24]([C:9]4[S:10][C:6]5[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[C:7]=5[N:8]=4)=[O:29])[CH2:22][CH2:23]3)=[CH:40][C:35]=2[O:34][CH2:33][CH2:32]1

Participants

4

Reactant 3

HCID 182724-MethylbenzothiazoleHCID 2481272,3-Dihydro-1,4-benzodioxin-6-carbaldehydeHCID 178502731HCID 178502731, compound

Product 1

HCID 178424117HCID 178424117, compound

Procedure

Using 4-methyl-benzothiazole (5 mmol), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.5 mmol) and 2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde (0.3 mmol) according to the same protocol as that described for example 1, steps 1.a to 1.c, the title compound was obtained as a colourless solid (58 mg).

Sources & evidence

ORD record
ord-3e386b6385a24f3092ca9f6d5513301d
Source dataset
uspto-grants-2011_07
Patent number
US07981886B2

Reaction notes

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