6-Methoxybenzothiazole → HCID 178487972, compound

HRID 1012918Notes

Reaction equation

HRID 1012918 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]2[N:7]=[CH:8][S:9][C:5]=2[CH:4]=1.C(O[C:17](=O)[NH:18][C@H:19]1[CH2:24][CH2:23][C@H:22]([C:25](=[O:30])N(OC)C)[CH2:21][CH2:20]1)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40](C=O)[CH:41]=[CH:42][C:36]=2[O:35][CH2:34]1>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]2[N:7]=[C:8]([C:25]([C@H:22]3[CH2:21][CH2:20][C@H:19]([NH:18][CH2:17][C:40]4[CH:41]=[CH:42][C:36]5[O:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=5[CH:39]=4)[CH2:24][CH2:23]3)=[O:30])[S:9][C:5]=2[CH:4]=1

Participants

4

Reactant 3

HCID 3501866-MethoxybenzothiazoleHCID 107736383-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carbaldehydeHCID 178502731HCID 178502731, compound

Product 1

HCID 178487972HCID 178487972, compound

Procedure

The title compound was prepared according to the same protocol as that described for example 1, steps 1.a to 1.c, using 6-methoxy-benzothiazole (5 mmol), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.5 mmol) and 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde (0.3 mmol). A yellowish solid (43 mg) was obtained.

Sources & evidence

ORD record
ord-f07c4eed64214f04bec999e4850fc67e
Source dataset
uspto-grants-2011_07
Patent number
US07981886B2

Reaction notes

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