2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde → HCID 178487973, compound

HRID 1012919Notes

Reaction equation

HRID 1012919 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]2[N:7]=[CH:8][S:9][C:5]=2[CH:4]=1.C(O[C:17](=O)[NH:18][C@H:19]1[CH2:24][CH2:23][C@H:22]([C:25](=[O:30])N(OC)C)[CH2:21][CH2:20]1)(C)(C)C.[O:32]1[C:37]2[CH:38]=[CH:39][C:40](C=O)=[CH:41][C:36]=2[O:35][CH2:34][CH2:33]1>>[O:32]1[C:37]2[CH:38]=[CH:39][C:40]([CH2:17][NH:18][C@H:19]3[CH2:20][CH2:21][C@H:22]([C:25]([C:8]4[S:9][C:5]5[CH:4]=[C:3]([O:2][CH3:1])[CH:11]=[CH:10][C:6]=5[N:7]=4)=[O:30])[CH2:23][CH2:24]3)=[CH:41][C:36]=2[O:35][CH2:34][CH2:33]1

Participants

4

Reactant 3

HCID 2481272,3-Dihydro-1,4-benzodioxin-6-carbaldehydeHCID 3501866-MethoxybenzothiazoleHCID 178502731HCID 178502731, compound

Product 1

HCID 178487973HCID 178487973, compound

Procedure

Using 6-methoxy-benzothiazole (5 mmol), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.5 mmol) and 2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde (0.3 mmol) according to the same protocol as that described for example 1, steps 1.a to 1.c, the title compound was obtained as a yellowish solid (92 mg).

Sources & evidence

ORD record
ord-9ceb9b9f528a4ea2bc2eaf94e080ad4e
Source dataset
uspto-grants-2011_07
Patent number
US07981886B2

Reaction notes

Loading…