2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde → HCID 178466162, compound

HRID 1012926Notes

Reaction equation

HRID 1012926 reaction equation
[CH2:1]([O:3][C:4]1[C:9]2[N:10]=[CH:11][S:12][C:8]=2[CH:7]=[CH:6][CH:5]=1)[CH3:2].C(O[C:18](=O)[NH:19][C@H:20]1[CH2:25][CH2:24][C@H:23]([C:26](=[O:31])N(OC)C)[CH2:22][CH2:21]1)(C)(C)C.[O:33]1[C:38]2[CH:39]=[CH:40][C:41](C=O)=[CH:42][C:37]=2[O:36][CH2:35][CH2:34]1>>[O:33]1[C:38]2[CH:39]=[CH:40][C:41]([CH2:18][NH:19][C@H:20]3[CH2:21][CH2:22][C@H:23]([C:26]([C:11]4[S:12][C:8]5[CH:7]=[CH:6][CH:5]=[C:4]([O:3][CH2:1][CH3:2])[C:9]=5[N:10]=4)=[O:31])[CH2:24][CH2:25]3)=[CH:42][C:37]=2[O:36][CH2:35][CH2:34]1

Participants

4

Reactant 3

HCID 2481272,3-Dihydro-1,4-benzodioxin-6-carbaldehydeHCID 22218898HCID 22218898, compoundHCID 178502731HCID 178502731, compound

Product 1

HCID 178466162HCID 178466162, compound

Procedure

Using 4-ethoxy-benzothiazole (5 mmol), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.5 mmol) and 2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde (0.3 mmol) according to the same protocol as that described for example 1, steps 1.a to 1.c, the title compound was obtained as an off-white solid (6 mg).

Sources & evidence

ORD record
ord-04e8060680d3432c92ac357a47f0463e
Source dataset
uspto-grants-2011_07
Patent number
US07981886B2

Reaction notes

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