3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carbaldehyde → HCID 178489951, compound

HRID 1012927Notes

Reaction equation

HRID 1012927 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[CH:10][S:11][C:7]=2[C:6]([CH3:12])=[CH:5][CH:4]=1.C(O[C:18](=O)[NH:19][C@H:20]1[CH2:25][CH2:24][C@H:23]([C:26](=[O:31])N(OC)C)[CH2:22][CH2:21]1)(C)(C)C.[O:33]=[C:34]1[NH:39][C:38]2[CH:40]=[C:41](C=O)[CH:42]=[CH:43][C:37]=2[S:36][CH2:35]1>>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([C:26]([C@H:23]3[CH2:22][CH2:21][C@H:20]([NH:19][CH2:18][C:41]4[CH:42]=[CH:43][C:37]5[S:36][CH2:35][C:34](=[O:33])[NH:39][C:38]=5[CH:40]=4)[CH2:25][CH2:24]3)=[O:31])[S:11][C:7]=2[C:6]([CH3:12])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 109433483-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carbaldehydeHCID 23253797HCID 23253797, compoundHCID 178502731HCID 178502731, compound

Product 1

HCID 178489951HCID 178489951, compound

Procedure

Using 4-methoxy-7-methyl-benzothiazole (5 mmol; J. Org. Chem. (1984), 49, 997), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.5 mmol) and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbaldehyde (0.3 mmol) according to the same protocol as that described for example 1, steps 1.a to 1.c, the title compound was obtained as a yellowish solid (20 mg).

Sources & evidence

ORD record
ord-4c4e1e8cf74143909f55954af6865cb0
Source dataset
uspto-grants-2011_07
Patent number
US07981886B2

Reaction notes

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