3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carbaldehyde → HCID 178516914, compound

HRID 1012932Notes

Reaction equation

HRID 1012932 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[S:3][CH:2]=1.C(O[C:15](=O)[NH:16][C@H:17]1[CH2:22][CH2:21][C@H:20]([C:23](=[O:28])N(OC)C)[CH2:19][CH2:18]1)(C)(C)C.[O:30]=[C:31]1[NH:36][C:35]2[CH:37]=[C:38](C=O)[CH:39]=[CH:40][C:34]=2[S:33][CH2:32]1>>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[S:3][C:2]=1[C:23]([C@H:20]1[CH2:19][CH2:18][C@H:17]([NH:16][CH2:15][C:38]2[CH:39]=[CH:40][C:34]3[S:33][CH2:32][C:31](=[O:30])[NH:36][C:35]=3[CH:37]=2)[CH2:22][CH2:21]1)=[O:28]

Participants

4

Reactant 3

HCID 109433483-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carbaldehydeHCID 19831912Thiazolo(5,4-b)pyridineHCID 178502731HCID 178502731, compound

Product 1

HCID 178516914HCID 178516914, compound

Procedure

Using thiazolo[5,4-b]pyridine (10 mmol; Synthesis (1974), 120), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (5 mmol) and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbaldehyde (0.38 mmol) according to the same protocol as that described for example 1, steps 1.a to 1.c, the title compound was obtained as its hydrochloride salt (20 mg).

Sources & evidence

ORD record
ord-ccf1679ddd8e40dcaeab7e8f07277eb8
Source dataset
uspto-grants-2011_07
Patent number
US07981886B2

Reaction notes

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