3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carbaldehyde → HCID 11998934, compound

Participants

Reaction Steps

Using the same protocol as for example 23, steps 23.a) to 23.f, the title compound was synthesised using 4-methoxybenzothiazole (8.7 mmol), (3R,6S)-(6-formyl-tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester (4.6 mmol) and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbaldehyde (0.7 mmol) and obtained after chromatography on SiO2 (EtOAc/MeOH 9:1 +1% NH4OH) and crystallisation from ether/MeOH as a yellowish solid (35 mg).

Provenance & Evidence