Hydrochloric Acid → 5,5-dimethyl-3-[3-[(4-oxo-5,6,7,8-tetrahydro-3H-phthalazin-1-yl)methyl]phenyl]imidazolidine-2,4-dione

関与物質

反応手順

To a solution of methyl 2-methyl-2-[[3-[(4-oxo-5,6,7,8-tetrahydro-3H-phthalazin-1-yl)methyl]phenyl]carbamoylamino]propanoate (14) (44 mg, 0.11 mmol) in dry DMF (2 mL) was added finely powdered sodium hydroxide (4 mg, 0.072 mmol). The reaction mixture was immersed in a preheated oil bath at 50° C. for 5 hours, before being neutralized by addition of 1M HCl The desired product was isolated from the resultant solution by preparative chromatography to yield a solid (3.6 mg, 98% purity). M/z (LC-MS, ESP), RT=7.69 mins (M+H 367.1).

情報源と証拠