Hydrochloric Acid → 1-(4-Chloroplithalazin-1-yl)-N-methylpiperidin-4-amine dihydrochloride

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Reaction Steps

Add hydrogen chloride (4.0 N in dioxane, 100 mL; 400 mmol) to a solution of tert-butyl 1-(4-chlorophthalazin-1-yl)piperidin-4-yl(methyl)carbamate (7.60 g; 100 equiv; 20.2 mmol) in methanol (100 mL). Stir at room temperature one hour. Remove the solvent under reduced pressure to obtain the title compound (7.05 g, 100%). ES/MS m/z 277.2 (M+1).

Provenance & Evidence